Reaktion #1178413

Reaktionsgleichung

2,2-dimethoxypropane

p-toluenesulfonic acid monohydrate

→

(2,2-dimethyl-[1,3]dioxan-5-yl)-methanol

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwere added
2. 2
   SonstigeAs much solvent as possible was removed in vacuo
3. 3
   workup.DISTILLATIONthe remainder was purified by distillation under vacuum

Vorschrift

Triol 3-1 (1 eq.) was dissolved in DMF at a concentration of approximately 0.5 M and 2,2-dimethoxypropane (1.16 eq.) and p-toluenesulfonic acid monohydrate (0.03 eq.) were added. The solution was stirred for one or more days, and was quenched with TEA (0.5 eq.). As much solvent as possible was removed in vacuo and the remainder was purified by distillation under vacuum.

Quelle