Reaktion #1178392

Reaktionsgleichung

hydrochloric acid

2-hydroxyindane

paraformaldehyde

calcium chloride

→

chloromethyl(2-indanyl)ether

Ausbeute 100.3%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe reaction mixture was agitated for 16 hours
2. 2
   SonstigeAfter separated an organic layer from the mixture
3. 3
   Sonstigethe solvent was removed by distillation

Vorschrift

A mixture of 134 g of 2-hydroxyindane, 36.1 g of paraformaldehyde, 200 g of calcium chloride, and 1200 g of methylene chloride was agitated. Into the mixture was dropped 239 g of a concentrated hydrochloric acid at room temperature for 3 hours, and then the reaction mixture was agitated for 16 hours. After separated an organic layer from the mixture, the solvent was removed by distillation to obtain 183 g of chloromethyl(2-indanyl)ether as an oily matter.

Quelle