Reaktion #1173963

Reaktionsgleichung

methyl-2,4-dibromobutyrate

N-methyl-2,4-dibromobutyramide

N-methyl-2,4-dibromobutyramide

3-hydroxy-N-methylpyrrolidone

methyl-2,4-dibromobutyrate

→

3-bromo-N-methyl-2-pyrrolidone

3-hydroxy-N-methyl-2-pyrrolidone

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThere is also provided by this invention a method

Vorschrift

There is also provided by this invention a method for preparation of 3-hydroxy-N-methylpyrrolidone which comprises conversion of delta-butyrolactone to methyl-2,4-dibromobutyrate, conversion of the methyl-2,4-dibromobutyrate to N-methyl-2,4-dibromobutyramide, ring closure of the N-methyl-2,4-dibromobutyramide to form 3-bromo-N-methyl-2-pyrrolidone, and conversion of the 3-bromo-N-methyl-2-pyrrolidone to 3-hydroxy-N-methyl-2-pyrrolidone by reaction with alkali metal carbonate.

Quelle