Reaktion #11727

Reaktionsgleichung

chloroacetyl chloride

(2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine

triethylamine

→

title compound

Ausbeute 84.9%

2-Chloro-1-[4-(4-fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-ethanone

Ausbeute 84.9%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction mixture
2. 2
   FiltrationThe reaction was then filtered through a pad of celite
3. 3
   Waschenwashed with dichloromethane
4. 4
   Einengenthe resulting filtrate was concentrated

Vorschrift

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (2.5 g, 11.2 mmol) in dry dichloromethane (11 mL) at 0° C. was added triethylamine (1.57 mL, 11.2 mmol) followed by chloroacetyl chloride (0.86 mL, 11.2 mmol). The resulting reaction mixture was stirred for 30 minutes. The reaction was then filtered through a pad of celite, washed with dichloromethane and the resulting filtrate was concentrated. Chromatography on silica gel gave the title compound (2.84 g).

Quelle