Reaktion #1172664

Reaktionsgleichung

1,2-Epoxy-2,3-dihydro-1-H indene

indene

pyrrolidine

→

trans-2,3-dihydro-2-hydroxy-1-(pyrrolidin-1-yl)-1H-indene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeevaporated
2. 2
   Sonstigeto remove the excess pyrrolidine under reduced pressure
3. 3
   workup.DISTILLATIONThe residue was distilled under vacuum

Vorschrift

1,2-Epoxy-2,3-dihydro-1-H indene, prepared from indene (34.2 g) according to the procedure of M. Imuta and H. Ziffer, J. Org. Chem., 44, 1351 (1979), was treated immediately with pyrrolidine (50 ml). The exothermic reaction mixture was set aside for 15 minutes and then evaporated to remove the excess pyrrolidine under reduced pressure. The residue was distilled under vacuum to yield trans-2,3-dihydro-2-hydroxy-1-(pyrrolidin-1-yl)-1H-indene (10.2 g), b.p. 148°-150°/0.25 torr.

Quelle