Reaktion #1172481

Reaktionsgleichung

3-(4-nitrophenyl)propyl p-toluenesulfonate

3-hydroxypropylamine

water

chloroform

chloroform

→

N-(3-hydroxypropyl)-3-(4-nitrophenyl)propylamine

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONthe mixture was thoroughly mixed for separation
2. 2
   Waschenwashed with water
3. 3
   Trocknendried over sodium sulfate anhydrous
4. 4
   SonstigeThe solvent was removed in vacuo and 0.7 g of an oil of N-(3-hydroxypropyl-3-(4-nitrophenyl)propylamine
5. 5
   Sonstigewas obtained

Vorschrift

3-(4-nitrophenyl)propyl p-toluenesulfonate (1 g) and 4.1 ml of 3-hydroxypropylamine were dissolved in 10 ml of dioxane and the solution was stirred at 80° C. for 30 minutes. To the solution was added 100 ml of water and 100 ml of chloroform, and the mixture was thoroughly mixed for separation. The chloroform-layer fraction was taken, washed with water and then dried over sodium sulfate anhydrous. The solvent was removed in vacuo and 0.7 g of an oil of N-(3-hydroxypropyl-3-(4-nitrophenyl)propylamine was obtained.

Quelle