Reaktion #1172445

Reaktionsgleichung

above obtained compound

1,3-dimethyl-6-[4-(3-aminopropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

compound 59

1,3-dimethyl-6-[4-(3-aminopropyl)piperazin-1-yl]-2,4(1H,3H)-pyrimidinedione

4-nitrofluorobenzene

→

1,3-dimethyl-6-{4-[3-(4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione

Ausbeute 76.9%

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Sonstigethe deposited crystals were collected by filteration
3. 3
   Waschenwashed
4. 4
   Sonstigedried

Vorschrift

To 20 ml of dimethyl sulfoxide were added 2.50 g of the above obtained compound (compound 59) and 1.90 g of 4-nitrofluorobenzene, and the resulting mixture solution was heated at 80° C. for 3 hours. After cooling, the deposited crystals were collected by filteration, washed, and dried to obtain 2.75 g of 1,3-dimethyl-6-{4-[3-(4-nitroanilino)propyl]piperazin-1-yl}-2,4(1H,3H)-pyrimidinedione (compound 58').

Quelle