Reaktion #11705

Reaktionsgleichung

(2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine

7-methyl-chroman-2-one

→

title compound

Ausbeute 79.0%

1-[4-(4-Fluoro-benzyl)-(2R,5S)-2,5-dimethyl-piperazin-1-yl]-3-(2-hydroxy-4-methyl-phenyl)-propan-1-one

Ausbeute 79.0%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe resulting solution was heated
2. 2
   Temperaturto reflux for 48 hours
3. 3
   TemperaturThe reaction was cooled
4. 4
   Einengenconcentrated in vacuo
5. 5
   Sonstigepurified via chromatography on silica gel

Vorschrift

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (0.25 g, 1.12 mmol) in toluene (10 mL) was added 7-methyl-chroman-2-one (0.25 g, 1.54 mmol) and the resulting solution was heated to reflux for 48 hours. The reaction was cooled, concentrated in vacuo and purified via chromatography on silica gel to give the title compound (0.34 g).

Quelle