Reaktion #11676

Reaktionsgleichung

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Lithium hydroxide monohydrate

hydrochloric acid

→

title compound

Ausbeute 95.6%

(R)-1-carboxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

Ausbeute 95.6%

Lösungsmittel

tetrahydrofuran

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionwas followed by extraction with ethyl acetate (20 mL twice)
2. 2
   WaschenThe combined organic layers were washed with brine (10 mL)
3. 3
   Trocknendried over anhydrous sodium sulfate
4. 4
   Sonstigeevaporated under vacuum

Vorschrift

(R)-1-carbomethoxymethyl-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 7) (13 mg) was dissolved in a 2:2:1 mixture of tetrahydrofuran, methanol, and water (5 mL). Lithium hydroxide monohydrate (3 mg) was added, and the resulting mixture was stirred at room temperature for 2 h. Addition of 1.0 M aqueous hydrochloric acid (10 mL) was followed by extraction with ethyl acetate (20 mL twice). The combined organic layers were washed with brine (10 mL), dried over anhydrous sodium sulfate, and evaporated under vacuum to provide the title compound (12 mg). HPLC/MS [M+H]+, 398.

Quelle