Reaktion #11669

Reaktionsgleichung

hydrogen chloride

(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

→

(R)-3-amino-3,4-dihydrocarbostyril hydrochloride

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated under vacuum
2. 2
   Sonstigeevaporated under vacuum

Vorschrift

(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (178 mg) was dissolved in 4 M hydrogen chloride in 1,4-dioxane solution (10 mL) at 0° C. After 1 h the solution was slowly warmed to room temperature over 2 h. The solvent was evaporated under vacuum, and the residue was twice taken up in toluene (10 mL) and evaporated under vacuum to provide (R)-3-amino-3,4-dihydrocarbostyril hydrochloride, a white solid (132 mg).

Quelle