Reaktion #1165586

ord-af4fb97e00dd478d84951f8bed2392b8

Reaktionsgleichung

CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1
N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine
O=C(O)[C@H](O)[C@@H](O)C(=O)O
L-(+)-tartaric acid
→
CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1.O.O.O=C(O)C(O)C(O)C(=O)O
N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (+)tartrate dihydrate

Edukte

CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1
N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine
O=C(O)[C@H](O)[C@@H](O)C(=O)O
L-(+)-tartaric acid

Reagenzien

Keine

Lösungsmittel

—
IMS

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturto cool
  2. 2
    Sonstigecrystallised
  3. 3
    FiltrationThe salt was collected by filtration
  4. 4
    Sonstigerecrystallised from IMS

Vorschrift

N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (2.57 g) and L-(+)-tartaric acid (1.39 g) were dissolved in warm IMS (10 ml) and allowed to cool. On scratching a salt crystallised. The salt was collected by filtration and recrystallised from IMS to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (+)tartrate dihydrate, m.p. 76°-78° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05547972uspto-grants-1996_08