Reaktion #1165585

ord-176fe8cfeaad4179baa14c09c8aa8c87

Reaktionsgleichung

CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1
N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid
→
CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O
N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine citrate

Edukte

CC(C)(NCCCn1ccnc1)c1ccc(Cl)cc1
N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine
O=C(O)CC(O)(CC(=O)O)C(=O)O
citric acid

Reagenzien

Keine

Lösungsmittel

—
IMS

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturto cool
  2. 2
    Sonstigecrystallised
  3. 3
    FiltrationThe salt was collected by filtration
  4. 4
    Sonstigetriturated with ethyl acetate/methanol (1:1)
  5. 5
    Filtrationfiltered
  6. 6
    Sonstigedried

Vorschrift

N-[1-(4-Chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine (1.25 g) and citric acid (0.95 g) were dissolved in warm IMS (10 ml) and allowed to cool. After standing with occasional scratching a salt crystallised. The salt was collected by filtration, triturated with ethyl acetate/methanol (1:1) filtered and dried to give N-[1-(4-chlorophenyl)-1-methylethyl]-3-(imidazol-1-yl)propylamine citrate, m.p. 143°-145° C.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05547972uspto-grants-1996_08