Reaktion #1164097

Reaktionsgleichung

hydrochloric acid

2,7-Bis(4-phthalimidobutyryl)xanthene

4-phthalimidobutyryl chloride

xanthene

HCl

→

2,7-BIS(4-AMINOBUTYRYL)XANTHENE DIHYDROCHLORIDE

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITION9, 945 (1966), is treated with 700 ml
2. 2
   TemperaturThe mixture is heated
3. 3
   workup.STIRRINGis stirred
4. 4
   Temperaturrefluxed for an additional 24 hours
5. 5
   Temperaturcooled

Vorschrift

2,7-Bis(4-phthalimidobutyryl)xanthene, prepared from 4-phthalimidobutyryl chloride and xanthene by the method of S. S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with 700 ml. of hot glacial acetic acid after which 200 ml. of concentrated hydrochloric acid is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

Quelle