Reaktion #1163818

ord-34b39599fb554100a4b3c1db6bc7d92d

Reaktionsgleichung

O=C(c1ccccc1Cl)c1cc([N+](=O)[O-])ccc1-n1c(CN2CCCC2)nnc1CN1C(=O)c2ccccc2C1=O
2'-chloro-5-nitro2-[3-(pyrrolidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone
NN.O
hydrazine hydrate
→
O=[N+]([O-])c1ccc2c(c1)C(c1ccccc1Cl)=NCc1nnc(CN3CCCC3)n1-2
8-nitro-1-(pyrrolidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Edukte

O=C(c1ccccc1Cl)c1cc([N+](=O)[O-])ccc1-n1c(CN2CCCC2)nnc1CN1C(=O)c2ccccc2C1=O
2'-chloro-5-nitro2-[3-(pyrrolidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone
NN.O
hydrazine hydrate

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

In the manner given in Example 27, 2'-chloro-5-nitro2-[3-(pyrrolidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-nitro-1-(pyrrolidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03957761uspto-grants-1976_05