Reaktion #1163532

Reaktionsgleichung

4-amino-2,4'-dichlorobiphenyl ether

3,5-diiodo salicylic acid

phosphorus trichloride

→

3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy)-salicylanilide

Lösungsmittel

chlorobenzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONA mixture of 31.0 g
2. 2
   SonstigeThe hot solution is decanted from some insoluble residue
3. 3
   SonstigeUpon recrystallization from benzene, 27.8 g

Vorschrift

A mixture of 31.0 g. of 4-amino-2,4'-dichlorobiphenyl ether, 47.4 g. of 3,5-diiodo salicylic acid, and 4.3 ml. of phosphorus trichloride in 235 ml. of chlorobenzene is refluxed for 3 hours. The hot solution is decanted from some insoluble residue and the crude product settles out of solution upon cooling to room temperature. Upon recrystallization from benzene, 27.8 g. of 3,5-diiodo-3'-chloro-4'-(p-chlorophenoxy)-salicylanilide, m.p. 168°-170°C. is obtained.

Quelle