Reaktion #1163085

ord-b50c6dc5218d4d9292a1d02c01f59b91

Reaktionsgleichung

O=C(Cl)CCc1ccccc1
3-phenylpropionyl chloride
O=C(CCc1ccccc1)N1CCc2nnc(Cl)cc2C1
3-chloro-5,6,7,8-tetrahydro-6-(3-phenylpropionyl)pyrido[4,3-c]pyridazine
Clc1cc2c(nn1)CCNC2.O=C(O)/C=C\C(=O)O
3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine maleate
→
NNc1cc2c(nn1)CCN(C(=O)CCc1ccccc1)C2
3-Hydrazino-5,6,7,8-tetrahydro-6-(3-phenylpropionyl)pyrido[4,3-c]pyridazine

Edukte

O=C(Cl)CCc1ccccc1
3-phenylpropionyl chloride
O=C(CCc1ccccc1)N1CCc2nnc(Cl)cc2C1
3-chloro-5,6,7,8-tetrahydro-6-(3-phenylpropionyl)pyrido[4,3-c]pyridazine
—
Example 8 ( g )
Clc1cc2c(nn1)CCNC2.O=C(O)/C=C\C(=O)O
3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine maleate

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigemay be obtained in a manner analogous to

Vorschrift

The 3-chloro-5,6,7,8-tetrahydro-6-(3-phenylpropionyl)pyrido[4,3-c]pyridazine, required as starting material, may be obtained in a manner analogous to that described in Example 8 (g), from 28.6 g of 3-chloro-5,6,7,8-tetrahydropyrido[4,3-c]pyridazine maleate and 31.5 g of 3-phenylpropionyl chloride. M.P. 134°-137° from 95% ethanol.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US03954754uspto-grants-1976_05