Reaktion #1162220

ord-2e962e265d7d403a9c56ac86252538a3

Reaktionsgleichung

COC1=NS(=O)(=O)N=C1OC
3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide
Cc1cc(CN(C)C)oc1CSCCN
2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamine
Cc1cc(CN(C)C)oc1CSCCN
2-[(5-Dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamine
COC1=NS(=O)(=O)N=C1NCCSCc1oc(CN(C)C)cc1C
3-{2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide
CN
methylamine
→
CNC1=NS(=O)(=O)N=C1NCCSCc1oc(CN(C)C)cc1C
title compound
CNC1=NS(=O)(=O)N=C1NCCSCc1oc(CN(C)C)cc1C
3-{2-[(5-Dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamino}-4-methylamino-1,2,5-thiadiazole 1,1-dioxide

Edukte

COC1=NS(=O)(=O)N=C1OC
3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide
Cc1cc(CN(C)C)oc1CSCCN
2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamine
Cc1cc(CN(C)C)oc1CSCCN
2-[(5-Dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamine
COC1=NS(=O)(=O)N=C1NCCSCc1oc(CN(C)C)cc1C
3-{2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide
CN
methylamine

Reagenzien

Keine

Lösungsmittel

CO
methanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

When a methanol suspension of 3,4-dimethoxy-1,2,5-thiadiazole 1,1-dioxide is reacted with an equimolar amount of 2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamine [prepared in Step B] and the resultant 3-{2-[(5-dimethylaminomethyl-3-methyl-2-furyl)methylthio]ethylamino}-4-methoxy-1,2,5-thiadiazole 1,1-dioxide is treated with an excess of methylamine, the title compound is thereby produced.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04394508uspto-grants-1983_07