Reaktion #1162101

Reaktionsgleichung

4-mercaptopyridine

isopropyl iodide

→

product

4-Isopropylthiopyridine

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 4 hours
3. 3
   Sonstigeevaporated under reduced pressure
4. 4
   workup.DISSOLUTIONThe residue was dissolved in a small amount of water
5. 5
   Extraktionextracted with ethyl acetate
6. 6
   WaschenThe extract was washed with a small amount of water
7. 7
   Sonstigedried
8. 8
   Sonstigeevaporated under reduced pressure

Vorschrift

A mixture of 4-mercaptopyridine (555 mg, 5 mmoles) and isopropyl iodide (0.50 ml) in ethanol (5 ml) was heated under reflux for 4 hours and then evaporated under reduced pressure. The residue was dissolved in a small amount of water, made alkaline with aqueous sodium hydroxide and extracted with ethyl acetate. The extract was washed with a small amount of water, dried and evaporated under reduced pressure to give the product as an oil. Yield, 670 mg (88%).

Quelle