Reaktion #1161718

Reaktionsgleichung

1-bromo-3,3-diphenyl-2-propanone

1,3,4,7-tetrahydro-2H-1,3-diazepin-2-thione

→

desired product

3-Diphenylmethyl-2,3,5,8-tetrahydrothiazolo[3,2-a][1,3]-diazepin-3-ol hydrobromide

Lösungsmittel

acetone

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture is warmed
2. 2
   workup.STIRRINGstirred for 72 hours
3. 3
   TemperaturThe mixture is cooled
4. 4
   Filtrationthe resulting solid is collected by filtration

Vorschrift

This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 50 ml. of acetone and added to a warm solution of 1.28 g. of 1,3,4,7-tetrahydro-2H-1,3-diazepin-2-thione in 100 ml. of acetone. The reaction mixture is warmed, with stirring, for 3 hours and then stirred for 72 hours. The mixture is cooled and the resulting solid is collected by filtration, giving the desired product.

Quelle