Reaktion #1161716

Reaktionsgleichung

tetrahydro-2-pyrimidinethione

1,1-diphenyl-2-propanone

1-bromo-3,3-diphenyl-2-propanone

1-bromo-3,3-diphenyl-2-propanone

→

desired product

3-Diphenylmethyl-2,3,6,7,-tetrahydro-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

Lösungsmittel

acetone

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe resulting solid is collected by filtration

Vorschrift

A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone by the procedure of Example 22. The 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 0.80 g. of tetrahydro-2-pyrimidinethione in 70 ml. of acetone. This mixture is allowed to stand for 48 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 196°-198° C.

Quelle