Reaktion #1158000

ord-45f6a253f88b4a9d8cd2619d4e56cded

Reaktionsgleichung

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
CCOCc1nc2c(N)nc(C)c(C)c2n1CCCN
1-(3-aminopropyl)-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
CCOCc1nc2c(N)nc(C)c(C)c2n1CCCNC(=O)N[C@@H]1C[C@H]1c1ccccc1
desired compound
CCOCc1nc2c(N)nc(C)c(C)c2n1CCCNC(=O)N[C@@H]1C[C@H]1c1ccccc1
N-{3-[4-amino-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-1-yl]propyl}-N′-[(1R*,2S*)-2-phenylcyclopropyl]urea

Edukte

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
CCOCc1nc2c(N)nc(C)c(C)c2n1CCCN
1-(3-aminopropyl)-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 94-105, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(3-aminopropyl)-2-(ethoxymethyl)-6,7-dimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 437.2674.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06903113B2uspto-grants-2005_06