Reaktion #1157995

ord-910bdbdb61204ff19a814943cafc7174

Reaktionsgleichung

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
Cc1nc(N)c2nc(C)n(CCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
desired compound
Cc1nc(N)c2nc(C)n(CCCNC(=O)N[C@@H]3C[C@H]3c3ccccc3)c2c1C
N-[3-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)propyl]-N′-[(1R*,2S*)-2-phenylcyclopropyl]urea

Edukte

O=C=N[C@@H]1C[C@H]1c1ccccc1
trans-2-phenylcyclopropyl isocyanate
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the methods of Examples 75-85, trans-2-phenylcyclopropyl isocyanate was reacted with 1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 393.2393.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06903113B2uspto-grants-2005_06