Reaktion #1155354

Reaktionsgleichung

4-(4-benzyltriazol-2-yl)-1-benzylpiperidine

ammonium formate

→

product

Ausbeute 9.0%

4-(4-benzyltriazol-2-yl)piperidine

Ausbeute 9.0%

Lösungsmittel

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 1 h
2. 2
   FiltrationThe mixture was filtered through celite
3. 3
   Einengenconcentrated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in chloroform
5. 5
   Waschenthe solution was washed with 1M aqueous NaOH
6. 6
   TrocknenThe organic layer was dried over Na2SO4
7. 7
   Einengenconcentrated

Vorschrift

A mixture of 4-(4-benzyltriazol-2-yl)-1-benzylpiperidine (627 mg, 1.9 mmol, from Step B), 10% palladium on carbon (400 mg, 0.38 mmol) and ammonium formate (770 mg, 11.3 mmol) in 20 mL MeOH was refluxed for 1 h. The mixture was filtered through celite and concentrated. The residue was dissolved in chloroform and the solution was washed with 1M aqueous NaOH. The organic layer was dried over Na2SO4 and concentrated to afford 41 mg (9%) of product was obtained which was used in the next step without purification.

Quelle