Reaktion #11540

Reaktionsgleichung

hydrochloric acid

diethyl 2-methyl-2-(4-pyridylmethyl)malonate

→

2-methyl-3-(4-pyridyl)propionic acid

Ausbeute 100.3%

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was refluxed overnight
2. 2
   Waschenwashed with hexane (100 ml)
3. 3
   Sonstigeto remove sodium hydride oil
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   FiltrationThe resulting crystals were filtered off with ethyl acetate

Vorschrift

Next, 6 N hydrochloric acid (96.8 ml, 581 mmol) was added to diethyl 2-methyl-2-(4-pyridylmethyl)malonate (17.2 g, 64.6 mmol), and the mixture was refluxed overnight. The reaction mixture was allowed to stand, then washed with hexane (100 ml) to remove sodium hydride oil contained in diethyl 2-methyl-2-(4-pyridylmethyl)malonate, and concentrated under reduced pressure. The resulting crystals were filtered off with ethyl acetate to give 10.7 g (82%) of 2-methyl-3-(4-pyridyl)propionic acid as pale pink crystals.

Quelle