Reaktion #1152658

Reaktionsgleichung

p-benzyloxyamphetamine hydrochloride

4,4-di-(4-fluorophenyl)-butyl chloride

diisopropyl-ethylamine

→

1-(p-benzyloxyphenyl)-2-[4,4-di-(4-fluorophenyl)-butylamino]-propane hydrochloride

Lösungsmittel

dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeIt is evaporated
2. 2
   Waschenthe solution washed three times with water
3. 3
   SonstigeThe organic layer is dried
4. 4
   Sonstigeevaporated

Vorschrift

The mixture of 11.1 g of dl-p-benzyloxyamphetamine hydrochloride, 11.2 g of 4,4-di-(4-fluorophenyl)-butyl chloride, 10.34 g of diisopropyl-ethylamine and 50 ml of dimethylformamide is stirred at 100° for 60 hours. It is evaporated, the residue taken up in benzene and the solution washed three times with water. The organic layer is dried, evaporated, the residue taken up in diethyl ether and the solution acidified with hydrogen chloride in isopropanol to afford the dl-1-(p-benzyloxyphenyl)-2-[4,4-di-(4-fluorophenyl)-butylamino]-propane hydrochloride, melting at 130°-133°.

Quelle