Reaktion #11524

Reaktionsgleichung

triethylamine

3-Bromophenylethylamine hydrochloride

4-methylphenylsulphonyl chloride

→

product

Ausbeute 68.4%

2-[3-Bromophenyl]-N-(4-methylphenylsulphonyl)ethylamine

Ausbeute 68.4%

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solid was filtered off
2. 2
   Waschenwashed with THF
3. 3
   Sonstigethe filtrate evaporated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in ethyl acetate
5. 5
   Waschenwashed with 1N hydrochloric acid, water, brine
6. 6
   Trocknendried (MgSO4)
7. 7
   WaschenChromatography on flash silica, eluting with 0 to 25% ethyl acetate in isohexane

Vorschrift

3-Bromophenylethylamine hydrochloride (9.44 g) was added to THF (60 ml) containing triethylamine (12.24 ml) and stirred-under argon at 5° C. during the portionwise addition over 15 minutes of 4-methylphenylsulphonyl chloride (11.44 g). The slurry was diluted with THF (50 ml) and stirred for 16 h. The solid was filtered off, washed with THF and the filtrate evaporated. The residue was dissolved in ethyl acetate, washed with 1N hydrochloric acid, water, brine and dried (MgSO4). Chromatography on flash silica, eluting with 0 to 25% ethyl acetate in isohexane gave the product (9.67 g).

Quelle