Reaktion #11523

Reaktionsgleichung

water

4-(2-Chloroethyl)morpholine hydrochloride

1-benzothiophene-4-ol

potassium carbonate

dimethylformamide

→

product

2-[(1-Benzothien-4-yloxy)ethyl]morpholine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionextracted twice with ethyl acetate
3. 3
   WaschenThe combined solvent phase was washed twice with brine
4. 4
   Trocknendried (magnesium sulphate)
5. 5
   Sonstigeevaporated

Vorschrift

4-(2-Chloroethyl)morpholine hydrochloride (0.74 g), 1-benzothiophene-4-ol (0.5 g) and potassium carbonate (1.1 g) in dimethylformamide (15 ml) were heated and stirred at 80° C. for 6 h. After cooling, the mixture was poured into water and extracted twice with ethyl acetate. The combined solvent phase was washed twice with brine, dried (magnesium sulphate) and evaporated to give the product (0.7 g).

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