Reaktion #1151604

ord-4ac734ab4070457892fd4a9e8c61cc94

Reaktionsgleichung

O=C(Cl)[C@@H]1C[C@H]1c1ccccc1
trans-2-phenyl-1-cyclopropanecarbonyl chloride
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine
→
Cc1nc(N)c2nc(C)n(CCCNC(=O)[C@@H]3C[C@H]3c3ccccc3)c2c1C
desired product
Cc1nc(N)c2nc(C)n(CCCNC(=O)[C@@H]3C[C@H]3c3ccccc3)c2c1C
(1R*,2R*)-N-{3-[4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl]propyl}-2-phenylcyclopropanecarboxamide

Edukte

O=C(Cl)[C@@H]1C[C@H]1c1ccccc1
trans-2-phenyl-1-cyclopropanecarbonyl chloride
Cc1nc(N)c2nc(C)n(CCCN)c2c1C
1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 78-92, trans-2-phenyl-1-cyclopropanecarbonyl chloride was reacted with 1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 378.2298.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06969722B2uspto-grants-2005_11