Reaktion #1151296

Reaktionsgleichung

title compound

8-Amino-2-phenyl-1,5-dihydro-[1,2]diazepino[4,5,6-cd]indol-6-one

phenyl-acetic acid

triethylamine

O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate

→

title compound

Ausbeute 95.0%

N-(6-Oxo-2-phenyl-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl)-2-phenyl-acetamide

Ausbeute 95.0%

Lösungsmittel

CH2Cl2

methanol

hexane

CH2Cl2

N,N-dimethylformamide

Reaktionsbedingungen

Vorschrift

Preparation of example 25 from the title compound of Example 7 (hydrochloride) (20 mg, 0.072 mmol), phenyl-acetic acid (11 mg, 0.08 mmol), triethylamine (0.014 mL, 0.10 mmol), and O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (30 mg, 0.080 mmol) in CH2Cl2 (0.3 mL) and N,N-dimethylformamide (0.3 mL) was carried out analogously to Example 11. Silica gel chromatography (8:5:2 CH2Cl2:hexane:methanol), also in an analogous manner, afforded the title compound (27 mg, 0.068 mmol) as a yellow powder in 95% yield.

Quelle