Reaktion #11509

Reaktionsgleichung

3-(1-(4-butoxybenzoyl)-2-methylindol-4-yl)acrylic acid

hydrogen

→

title compound

Ausbeute 8.3%

3-(1-(4-Butoxybenzoyl)-2-methylindol-4-yl)propionic acid

Ausbeute 8.3%

Lösungsmittel

methanol ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered through Celite (trademark)
2. 2
   WaschenThe filtrate and washing with chloroform
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   SonstigeThe residue was purified by column chromatography on silica gel (chloroform-methanol)

Vorschrift

To a solution of 3-(1-(4-butoxybenzoyl)-2-methylindol-4-yl)acrylic acid (300 mg; prepared in Example 4) in methanol-ethyl acetate (5 ml+5 ml) was added palladium on activated carbon (100 mg) at room temperature. The inside of the vessel was replaced with hydrogen and the mixture was stirred at room temperature for 2 hours. The mixture was filtered through Celite (trademark). The filtrate and washing with chloroform were combined, and then concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (chloroform-methanol) to give the title compound (25 mg) having the following physical data.

Quelle