Reaktion #1148621

Reaktionsgleichung

4-chloro-3-methoxy-2-methylpyridine

hydrogen peroxide water

→

4-chloro-3-methoxy-2-methylpyridine N-oxide

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONthe reaction solution was distilled off under reduced pressure
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in chloroform
3. 3
   Waschenwashed with saturated sodium bicarbonate solution, and saturated salt water
4. 4
   Trocknendried over anhydrous sodium sulfate
5. 5
   workup.DISTILLATIONThe solvent was distilled off under reduced pressure

Vorschrift

36.98 g of 4-chloro-3-methoxy-2-methylpyridine (V) was dissolved in 685 ml of acetic acid and 92 ml of hydrogen peroxide water was added thereto and the resulting mixture was heated at 90° C. for 24 hours, and thereafter, the reaction solution was distilled off under reduced pressure. The resulting residue was dissolved in chloroform and washed with saturated sodium bicarbonate solution, and saturated salt water, and thereafter, dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to obtain 37.64 g of 4-chloro-3-methoxy-2-methylpyridine N-oxide (VI).

Quelle