Reaktion #1147805

Reaktionsgleichung

4,6-Dihydroxy-2-methylpyrimidine

nitric acid

→

4,6-dihydroxy-2-methyl-5-nitropyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwhile cooling the reaction flask
2. 2
   workup.ADDITIONAfter completion of addition
3. 3
   workup.WAITfollowed by another 1 h at room temperature
4. 4
   SonstigeA light pink solid was isolated by filtration
5. 5
   Waschenwashed with cold water (100 mL)
6. 6
   SonstigeThe solid was dried in a vacuum oven overnight

Vorschrift

Part A: 4,6-Dihydroxy-2-methylpyrimidine (60 g) was added in portions to fuming nitric acid (120 mL) at 0° C. while cooling the reaction flask. After completion of addition, the reaction was stirred an additional 1 h at 0° C. followed by another 1 h at room temperature. The reaction mixture was then poured over ice (200 g) and the ice was allowed to melt. A light pink solid was isolated by filtration and washed with cold water (100 mL). The solid was dried in a vacuum oven overnight to yield 4,6-dihydroxy-2-methyl-5-nitropyrimidine (72.5 g).

Quelle