Reaktion #1147657

Reaktionsgleichung

4-bromo-3,5-dimethoxybenzaldehyde

ethylene glycol

p-TSA

→

4-bromo-3,5-dimethoxybenzaldehyde ethylene acetal

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture was refluxed overnight
2. 2
   Sonstigeevaporated
3. 3
   SonstigeThe residue was purified by column chromatography (silica gel; eluent hexane/AcOEt 5:1 to 2:1)

Vorschrift

4-bromo-3,5-dimethoxybenzaldehyde (3 g) was dissolved in toluene (50 mL) and ethylene glycol (6.8 mL) and a catalytic amount of p-TSA were added. The mixture was refluxed overnight using a Dean Stark apparatus and evaporated. The residue was purified by column chromatography (silica gel; eluent hexane/AcOEt 5:1 to 2:1) to give 4-bromo-3,5-dimethoxybenzaldehyde ethylene acetal (2.63 g).

Quelle