Reaktion #11468

ord-cc77f4f09e094c4b9162f96456afaacd

Reaktionsgleichung

O=C(Cl)[C@@H]1C[C@H]1c1ccccc1
trans-2-phenyl-1-cyclopropanecarbonyl chloride
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCNCC1
2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)[C@@H]2C[C@H]2c2ccccc2)CC1
desired product
CCOCc1nc2c(N)nc(C)c(C)c2n1CCC1CCN(C(=O)[C@@H]2C[C@H]2c2ccccc2)CC1
2-(ethoxymethyl)-6,7-dimethyl-1-[2-(1-{[(1R*,2R*)-2-phenylcyclopropyl]carbonyl}piperidin-4-yl)ethyl]-1H-imidazo[4,5-c]pyridin-4-amine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using the method of Examples 61–75, trans-2-phenyl-1-cyclopropanecarbonyl chloride was reacted with 2-(ethoxymethyl)-6,7-dimethyl-1-(2-piperidin-4-ylethyl)-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired product. The observed accurate mass was 476.3039.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098221B2uspto-grants-2006_08