Reaktion #1146340

Reaktionsgleichung

Water

Methyl iodide

(5-bromo-2-fluorophenyl)methanol

sodium hydride

→

title compound

4-bromo-1-fluoro-2-(methoxymethyl)benzene

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe mixture was stirred for 1.5 h
2. 2
   Extraktionthe mixture was extracted with ethyl acetate
3. 3
   Waschenwashed with saturated brine
4. 4
   Sonstigedried
5. 5
   SonstigeThe solvent was evaporated under reduced pressure
6. 6
   Sonstigethe residue was purified by column chomatography (eluent, hexane→hexane:ethyl acetate=50:1)

Vorschrift

To a solution of (5-bromo-2-fluorophenyl)methanol (5.00 g) in THF (100 ml) was added 60% sodium hydride (1.08 g) at 0° C., and the mixture was stirred at room temperature for 30 min. Methyl iodide (3.80 ml) was added, and the mixture was stirred for 1.5 h. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate, washed with saturated brine and dried. The solvent was evaporated under reduced pressure and the residue was purified by column chomatography (eluent, hexane→hexane:ethyl acetate=50:1) to give the title compound (4.86 g) as a brown oil.

Quelle