Reaktion #11457

Reaktionsgleichung

Triethylamine

1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

isobutyryl chloride

→

N-[3-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)propyl]-2-methylpropanamide

Ausbeute 25.3%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe solution was cooled in an ice bath
2. 2
   Sonstigethe ice bath was removed
3. 3
   workup.STIRRINGthe reaction mixture was stirred for an additional 15 minutes
4. 4
   workup.ADDITIONThe reaction mixture was diluted with chloroform to a volume of 150 mL
5. 5
   workup.ADDITIONWater (50 mL) was added
6. 6
   SonstigeThe resulting precipitate was isolated by filtration
7. 7
   Sonstigedried

Vorschrift

Triethylamine (0.78 mL, 5.6 mmol) was added to a solution of 1-(3-aminopropyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine (1.00 g, 4.3 mmol) in chloroform (50 mL). The solution was cooled in an ice bath and then isobutyryl chloride (0.49 mL, 4.7 mmol) was added. The reaction mixture was stirred for 15 minutes then the ice bath was removed and the reaction mixture was stirred for an additional 15 minutes. The reaction mixture was diluted with chloroform to a volume of 150 mL. Water (50 mL) was added then the pH was adjusted to 11 with solid potassium carbonate and then to pH 14 with 50% sodium hydroxide. The resulting precipitate was isolated by filtration and dried to provide 0.33 g of N-[3-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)propyl]-2-methylpropanamide as a white solid, m.p. 178.1–178.8° C.

Quelle