Reaktion #1144442

ord-4287cf64a9934602815a1f2ffdeebfa7

Reaktionsgleichung

CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
bupivacaine
CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
bupivacaine
CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
bupivacaine
CNC[C@H](O)c1ccc(O)c(O)c1
epinephrine
CN[C@@H](C)[C@H](O)c1ccccc1
Ephedrine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeare prepared, in a percent loading of about 0.05 percent, by weight
  2. 2
    workup.ADDITIONIn addition, microspheres containing

Vorschrift

Microspheres containing bupivacaine loaded to about 75 percent by weight with bupivacaine are prepared, in a percent loading of about 0.05 percent, by weight, using the methods described in EXAMPLES 1-3 or EXAMPLES 4-9, above. In addition, microspheres containing added epinephrine, in a percent loadings of 0.001 percent, 0.05 percent and 1 percent, without bupivacaine, are also prepared according to EXAMPLES 1-3 or EXAMPLES 4-9, above.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US06514516B1uspto-grants-2003_02