Reaktion #1142814

Reaktionsgleichung

3-oxo-3-(pyridin-3-yl)propionitrile

(2,2-diethoxyethyl)hydrazine

hydrochloric acid

→

1-(2,2-Diethoxyethyl)-3-(pyridin-3-yl)-1H-pyrazole-5-amine

Lösungsmittel

ethyl acetate

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was heated
2. 2
   Temperaturunder reflux for 4 h
3. 3
   Sonstigeall volatile components were then substantially removed on a rotary evaporator
4. 4
   SonstigeThe residue obtained
5. 5
   Waschenthe solution was washed with water
6. 6
   Trocknendried over anhydrous magnesium sulphate
7. 7
   FiltrationAfter filtration
8. 8
   Sonstigethe mixture was evaporated to dryness
9. 9
   SonstigeThe residue that remained was triturated with diisopropyl ether at RT
10. 10
    FiltrationThe resulting solid was then filtered off with suction
11. 11
    Sonstigedried under high vacuum

Vorschrift

With gentle heating, 125 g (812 mmol, purity 95%) of 3-oxo-3-(pyridin-3-yl)propionitrile [lit. for example: P. Seneci et al., Synth. Commun. 1999, 29 (2), 311-341; also available commercially] were dissolved in 1.25 liters of ethanol. 126 g (853 mmol) of (2,2-diethoxyethyl)hydrazine and 4.1 ml (4.06 mmol) of 1 M hydrochloric acid were then added. The reaction mixture was heated under reflux for 4 h, and all volatile components were then substantially removed on a rotary evaporator. The residue obtained was taken up in ethyl acetate, and the solution was washed with water and dried over anhydrous magnesium sulphate. After filtration, the mixture was evaporated to dryness. The residue that remained was triturated with diisopropyl ether at RT. The resulting solid was then filtered off with suction and dried under high vacuum. This gave 153 g (65% of theory, purity 96%) of the title compound.

Quelle