Reaktion #1142412

Reaktionsgleichung

3-amino-2,2-dimethyl-propan-1-ol

diketene

→

colorless solid

Ausbeute 73.0%

N-(3-Hydroxy-2,2-dimethylpropyl)-3-oxobutanamide

Ausbeute 73.0%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was evaporated
2. 2
   Sonstigethe residue is recrystallized from 150 ml of ethyl acetate

Vorschrift

A solution of 32.2 g (0.31 mol) of 3-amino-2,2-dimethyl-propan-1-ol in 60 ml tetrahydrofuran was added dropwise to a solution of 25 g of diketene (0.30 mol) in 200 ml tetrahydrofuran at −5 to 0° C. After 1 h stirring at 0° C. no more starting material was detected by thin layer chromatography. The reaction mixture was evaporated and the residue is recrystallized from 150 ml of ethyl acetate. This gave 40.6 g (0.21 mol, 73% yield) of a colorless solid.

Quelle