Reaktion #1142153

Reaktionsgleichung

(E)-6-chloro-5,8-dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyridine

→

desired product

Ausbeute 67.8%

6-Chloro-5,8-dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)ethyl)-[1,2,4]triazolo[1,5-a]pyridine

Ausbeute 67.8%

Lösungsmittel

Ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered over Celite
2. 2
   EinengenThe mixture was concentrated
3. 3
   Sonstigepurified by preparative HPLC

Vorschrift

Ethyl acetate was added to (E)-6-chloro-5,8-dimethyl-2-(2-(1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl)vinyl)-[1,2,4]triazolo[1,5-a]pyridine (15 mg). Palladium (5 wt. %) on barium sulfate (20 mg) was added. The mixture was stirred for 5 h under a hydrogen atmosphere and then filtered over Celite. The mixture was concentrated and purified by preparative HPLC to give the desired product (10.2 mg, 67.8%) as a light yellow powder. MS: m/z=360.5 (M+H+)

Quelle