Reaktion #11416

Reaktionsgleichung

1-(4-methoxy-phenyl)-propan-2-one

dimethoxymethyl-dimethyl-amine

N-(2-hydroxyethyl)phthalimide

→

4-dimethylamino-3-(4-methoxyphenyl)-but-3-en-2-one

4-Dimethylamino-3-(4-methoxy-phenyl)-but-3-en-2-one

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool to ambient temperature
2. 2
   Sonstigeexcess solvent and reagents were removed under reduced pressure

Vorschrift

To a stirred solution of 1-(4-methoxy-phenyl)-propan-2-one (1, 8.37 g, 51.0 mmol) in N,N-dimethylformamide (200 mL) was added dimethoxymethyl-dimethyl-amine (2, 27 mL, 203 mmol). The reaction mixture was then stirred for 18 h at 85° C., allowed to cool to ambient temperature and excess solvent and reagents were removed under reduced pressure to give crude 4-dimethylamino-3-(4-methoxyphenyl)-but-3-en-2-one (3) as yellow oil which was used in the following step without further purification.

Quelle