Reaktion #11390

Reaktionsgleichung

5-Amino-1-(2′,4′-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid

3-hydroxy-5-methylpyrrolidine

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titled product

Ausbeute 64.0%

5-Amino-1-(2′,4′-difluorophenyl)-6,8-difluoro-1,4-dihydro-7-(3′-hydroxy-5′-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

Ausbeute 64.0%

Reaktionsbedingungen

Vorschrift

The condensation of 5-Amino-1-(2′,4′-difluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-hydroxy-5-methylpyrrolidine in a similar manner as described in example 1 gave the titled product. Yield 64%, m.p ° C., C21H17F4N3O4, m/z 453. (M+1)

Quelle