Reaktion #11386

ord-52e4e58da95a46789156c6f37fe17043

Reaktionsgleichung

O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O
1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
CC(=O)NC1CNC(C)C1
3-acetamido-5-methylpyrrolidine
→
CC(=O)NC1CC(C)N(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1
titled product
CC(=O)NC1CC(C)N(c2cc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C1
1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(3′-acetamido-5′-methylpyrrolidin-1-yl)-4-oxo-quinoline-3-carboxylic acid

Edukte

O=C(O)c1cn(C2CC2)c2cc(Cl)c(F)cc2c1=O
1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
CC(=O)NC1CNC(C)C1
3-acetamido-5-methylpyrrolidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The condensation of 1-cyclopropyl-6-fluoro-7-chloro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid with 3-acetamido-5-methylpyrrolidine in a similar manner as described in example 1 give the titled product. Yield (68%), m.p 270–72° C., C20H22FN3O4, m/z 388 (M+1).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098219B2uspto-grants-2006_08