Reaktion #11370

ord-8f314dafc04e4e4c80a2a27202844908

Reaktionsgleichung

CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
compound
CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one
O=S(=O)(Cl)CCCCl
3-chloropropanesulfonyl chloride
c1ccncc1
pyridine
→
CCCOc1ccc(NS(=O)(=O)CCCCl)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
2-[5-(3-Chloropropanesulfonamido)-2-propoxyphenyl]-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Edukte

CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
compound
CCCOc1ccc(N)cc1-c1nn2c(C3CCCC3)nc(C)c2c(=O)[nH]1
2-(5-Amino-2-propoxyphenyl)-5-methyl-7-cyclopentyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one
O=S(=O)(Cl)CCCCl
3-chloropropanesulfonyl chloride
c1ccncc1
pyridine

Reagenzien

Keine

Lösungsmittel

ClCCl
dichloromethane

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

368 mg (1.0 mmol) of the compound from example 44A are reacted with 266 mg (1.5 mmol) of 3-chloropropanesulfonyl chloride and 0.81 ml (10.0 mmol) of pyridine in 12 ml of dichloromethane for 3 hours.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07098207B2uspto-grants-2006_08