Reaktion #1136770

Reaktionsgleichung

1-(2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)biphenyl-2-yl)-3,3-dimethylbutan-1-ol

tris(pentafluorophenyl)borane

trimethylsilyl cyanide

→

title compound

2-(2′-fluoro-4-hydroxy-5′-methoxybiphenyl-2-yl)-4,4-dimethylpentanenitrile

Lösungsmittel

acetonitrile

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe diluted solution was washed with water and saturated brine
2. 2
   Trocknendried over anhydrous sodium sulfate
3. 3
   SonstigeThe solvent was evaporated under reduced pressure
4. 4
   Sonstigethe residue was purified by silica gel column chromatography (ethyl acetate/hexane)

Vorschrift

To a solution of 1-(2′-fluoro-5′-methoxy-4-((4-methoxybenzyl)oxy)biphenyl-2-yl)-3,3-dimethylbutan-1-ol (160 mg) and tris(pentafluorophenyl)borane (20 mg) in acetonitrile (3 mL) was added trimethylsilyl cyanide (81 μL), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was diluted with ethyl acetate. The diluted solution was washed with water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (97 mg) as a colorless oil.

Quelle