Reaktion #11365

Reaktionsgleichung

bromoacetyl bromide

compound

2-(2-Ethoxyphenyl)-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one

AlCl3

→

2-[5-(2-Bromoacetyl)-2-ethoxyphenyl]-5-ethyl-7-propyl-3H-imidazo[5,1-f][1,2,4]-triazin-4-one

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated
2. 2
   Temperaturat reflux for 2 h
3. 3
   Extraktionextraction with CH2Cl2
4. 4
   Trocknendrying over MgSO4 and concentration under reduced pressure
5. 5
   Sonstigethe residue was triturated with ether
6. 6
   SonstigeThis gave 1.33 g (33% pure according to LC-MS) of the desired product which was reacted further without further purification

Vorschrift

A solution, cooled to 0° C., of 1 g (3.1 mmol) of the compound from example 17A in 80 ml of CH2Cl2 was admixed dropwise with 1.2 g (6.1 mmol) of bromoacetyl bromide and a little at a time with 1.2 g (9.1 mmol) of AlCl3. The reaction mixture was warmed to room temperature (30 min.) and then heated at reflux for 2 h and carefully poured into ice-water. Following extraction with CH2Cl2, drying over MgSO4 and concentration under reduced pressure, the residue was triturated with ether. This gave 1.33 g (33% pure according to LC-MS) of the desired product which was reacted further without further purification.

Quelle