Reaktion #1135820

Reaktionsgleichung

methyl laurate

dimethylaminobutanol

→

3-dimethylaminopropyl laurate

Ausbeute 67.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA syringe was inserted
2. 2
   Sonstigethrough the cap
3. 3
   SonstigeNitrogen was bubbled at a rate sufficient
4. 4
   workup.ADDITIONto mix the contents
5. 5
   Sonstigeset to 65° C
6. 6
   Temperaturto cool
7. 7
   SonstigeThe Novozym 435 was removed by filtration
8. 8
   Sonstigeto afford the product as a pale, yellow oil (9.2 g; 67% yield)
9. 9
   Sonstigewithout further purification

Vorschrift

To a 50-mL conical bottom plastic vial was added methyl laurate (38.5 mmol), dimethylaminobutanol (46.2 mmol, 1.2 eq), and Novozym 435 (400 mg). A syringe was inserted through the cap and two additional holes were punched for gas to exit. Nitrogen was bubbled at a rate sufficient to mix the contents. The vial was placed in a heating block set to 65° C. The reaction was monitored by GC/MS to observe the disappearance of starting material. The reaction was complete after approximately 24 hours. The reaction mixture was allowed to cool. The Novozym 435 was removed by filtration to afford the product as a pale, yellow oil (9.2 g; 67% yield) without further purification.

Quelle