Reaktion #1135805

Reaktionsgleichung

sodium bicarbonate

1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one

potassium carbonate

dimethyl sulfate

→

1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeTo the reaction mixtures
2. 2
   Extraktionthe mixtures were extracted with ethyl acetate
3. 3
   WaschenThe organic layers were washed with aqueous saturated sodium bicarbonate solution
4. 4
   Trocknenwere dried over anhydrous sodium sulfate
5. 5
   EinengenThe resulting mixtures were concentrated under reduced pressure

Vorschrift

A mixture of the above-mentioned 1-(2-methyl-3-iodophenyl)-1,4-dihydrotetrazole-5-one, potassium carbonate 17.40 g, dimethyl sulfate 5.78 g and N,N-dimethylformamide 150 mL was stirred at 25° C. for one hour. To the reaction mixtures was added aqueous saturated sodium bicarbonate solution and the mixtures were extracted with ethyl acetate. The organic layers were washed with aqueous saturated sodium bicarbonate solution and were dried over anhydrous sodium sulfate. The resulting mixtures were concentrated under reduced pressure to give 1-(2-methyl-3-iodophenyl)-4-methyl-1,4-dihydrotetrazole-5-one (hereinafter, referred to as “Intermediate (PRI-P)”) 8.10 g.

Quelle