Reaktion #1132856

Reaktionsgleichung

3-oxo-3-(2-phenyl-pyrimidin-4-yl)-propionic acid ethyl ester

N-methylthiourea

1,8-diazabicyclo[5,4,0]undec-7-en

hydrochloric acid

→

2-mercapto-1-methyl-2′-phenyl-1H-[4,4′]bipyrimidinyl-6-one

Ausbeute 93.0%

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturunder reflux for 18 hours
2. 2
   Sonstigewas removed under reduced pressure
3. 3
   Filtrationthe resulting solid was filtered
4. 4
   Waschenwashed with water
5. 5
   Sonstigedried

Vorschrift

A solution of 3-oxo-3-(2-phenyl-pyrimidin-4-yl)-propionic acid ethyl ester (2.74 g, 10.1 mmol), N-methylthiourea (1.39 g, 15.5 mmol) and 1,8-diazabicyclo[5,4,0]undec-7-en (1.57 g, 10.3 mmol) in ethanol (30 ml) was heated under reflux for 18 hours. After the solution was acidified by addition of hydrochloric acid, ethanol was removed under reduced pressure, and the resulting solid was filtered, washed with water and dried to afford 2-mercapto-1-methyl-2′-phenyl-1H-[4,4′]bipyrimidinyl-6-one (2.78 g, 93%).

Quelle