Reaktion #1132690

Reaktionsgleichung

5-chloro-3-(4-methoxy-benzyl)-3,4-dihydro-1h-pyrido[2,3-d]pyrimidin-2-one

4-quinoxalin-2-ylphenol

cesium carbonate

→

280

Ausbeute 42.7%

3-(4-Methoxy-benzyl)-5-(4-quinoxalin-2-yl-phenoxy)-3,4-dihydro-1H-pyrido[2,3-d]pyrimidin-2-one

Ausbeute 42.7%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction was concentrated
2. 2
   workup.DISSOLUTIONredissolved in DMSO
3. 3
   Filtrationsyringe filtered
4. 4
   Sonstigepurified via prep HPLC

Vorschrift

A suspension of 5-chloro-3-(4-methoxy-benzyl)-3,4-dihydro-1h-pyrido[2,3-d]pyrimidin-2-one (100.00 mg; 0.33 mmol; 1.00 eq.), 4-quinoxalin-2-ylphenol (91.46 mg; 0.41 mmol; 1.25 eq.), and cesium carbonate (214.54 mg; 0.66 mmol; 2.00 eq.) in DMF (2.00 ml) was heated in a microwave at 130° C. for 4 hours. The reaction was concentrated, redissolved in DMSO, syringe filtered, and purified via prep HPLC to afford 69 mg of 280 as an off-white solid. LC-MS (M+H=490, obsd.=490).

Quelle